2025 Lexus IS 350 vs. 2025 Mercedes-Benz E-Class Review

Picture of the 2025 Lexus IS 350

2025 Lexus
IS 350

MSRP*: $43,760 to $47,835
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Picture of the 2025 Mercedes-Benz E-Class

2025 Mercedes-Benz
E-Class

MSRP*: $62,450 to $70,850
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MPG - City 19 - 20 MPG 22 - 25 MPG
MPG - Hwy 26 - 28 MPG 31 - 33 MPG
Seating Capacity 5 seats 5 seats
Cargo Space Info not available Info not available
Engine
  • 311-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)
  • 255-hp, 2.0-liter, 4 Cylinder Engine (Gasoline/Mild Electric Hybrid)
  • 375-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid)
Transmission Automatic Automatic
Drivetrain All Wheel Drive, Rear Wheel Drive All Wheel Drive, Rear Wheel Drive
Horsepower 311 hp 255 - 375 hp
Exterior Length 185.4 in 194.9 in
Exterior Width 72.4 in 73.7 in
Leg Room Front 44.8 in
Rear 32.2 in
Front 41.3 in
Rear 35.8 in
Head Room Front 38.2 in
Rear 36.9 in
Front 37.9 in
Rear 38.2 in

*MSRP and Invoice prices displayed are for educational purposes only, do not reflect the actual selling price of a particular vehicle, and do not include applicable gas taxes or destination charges.

Comparison Review

Comfort
Passengers in the back seat will be able to stretch out a lot more in the Mercedes-Benz E-Class than the Lexus IS 350, due to its greater head- and legroom. The Lexus IS 350 will be a favorite with taller drivers due to its greater front head- and legroom than the Mercedes-Benz E-Class.

Convenience
With the Mercedes-Benz E-Class you will definitely be making less frequent stops at the gas station than with the Lexus IS 350, due to its tank size and fuel economy.

Cost
There are a lot of factors to consider when calculating the overall cost of a vehicle. The main consideration is Manufacturer's Suggested Retail Price (MSRP). Based on MSRP, the Lexus IS 350 is clearly a better financial choice over the Mercedes-Benz E-Class.

Dimensions
The Lexus IS 350 is a little narrower than the Mercedes-Benz E-Class, so you'll have an easier time getting in and out of the car in a tight parking spot. If you go with the Lexus IS 350, you'll have a much easier time finding a large enough space to park than you will with the Mercedes-Benz E-Class.

Handling
The Lexus IS 350 has a smaller turning radius than the Mercedes-Benz E-Class, allowing you to more easily maneuver in and out of tight spots.

Performance
When it comes to horsepower, the Lexus IS 350 is somewhat more powerful than the Mercedes-Benz E-Class.

Powertrain
With its lower torque, the Lexus IS 350 doesn't do as good a job transmitting power to its wheels as the Mercedes-Benz E-Class.

Utility
In terms of seating you'll be able to fit the same number of people in both the Lexus IS 350 and the Mercedes-Benz E-Class.